Dr. Bruce Chorpita presenting: "Will clinical science ever guide clinical service at scale? Rethinking our knowledge architecture to increase the therapeutic intelligence of individuals and institutions."

Despite five decades of investment in mental health intervention research, the vast majority of the evidence base goes unused, and the annual global cost of mental health challenges exceeds $1.15 trillion. The case will be made for a fundamental reorganizing of the evidence base to improve its retrieval and actionability at an order of magnitude, allowing humans to help one another lead healthier lives. Working examples from our clinical trials and large-scale industrial implementation efforts will be used to illustrate the concept of "knowledge appliances" and the strategic coordination of people, evidence, and action to reduce the burden of mental health.