The Cal Dopamine Study (110714A)
The D’Esposito Lab is seeking healthy, young adults to participate in a pharmacological fMRI study. A sequence of screening and testing sessions take place on the UC Berkeley campus on separate days. Please note: this study requires roughly 18 hours of participation over 5 session; several sessions require up to 5-hour blocks of time. Individuals who complete this study will be eligible to take part in a second study at the Lawrence Berkeley Laboratory (see below).
1) 18-30 years old
2) Right handed
3) Current weight over 45 kgs (100 lbs)
4) Able to read and speak English fluently
5) Non-drinker or light social drinker (less than 7 drinks/week for women, 8 drinks/week for men)
6) No metal in your body and not claustrophobic
7) No history of a neurological or psychiatric disorder, or recent history of substance abuse
8) Not currently using psychoactive medications or taking street drugs (you will be asked to take a urine test)
9) Willing to provide blood and saliva samples for genetic and health testing.
10) Not currently pregnant
Subjects are paid $10/hr for providing a saliva sample for genetic testing and variable amounts for participation in other parts of the study. Based on the estimated number of hours required, eligible subjects who complete the 5 session study will earn approximately $300-350 and those who complete the PET study earn an addition $250.
Each session is described below:
1. Eligibility session (30 minutes): you provide a saliva sample for genetic screening to determine if you are eligible to participate in the study. Genetic results take 4-8 weeks to process. Your eligibility will be determined upon receiving the results of your genetic test.
2. Medical screening session (2.5-3 hours): you will complete a comprehensive health screening with a nurse practitioner, a blood draw, and several questionnaires and behavioral tasks.
3-5. Pharmacological fMRI sessions (4.5-5 hours each): on three different days, you will be given either a one-time dose of an FDA-approved medication that temporarily changes your brain’s dopamine levels, or a placebo (sugar pill), and will participate in a magnetic resonance imaging (MRI) scan lasting about 1 hour, as well as a series of computer-based tasks.
Those who complete all 5 sessions will be offered the opportunity to take part in a two-session positron emission tomography (PET) study that will take place at LBNL.
To participate or learn more, e-mail us at CalBrainStudy@gmail.com
CPHS Approval #2010-01-567