Acetylcholine and Spatial Working Memory (012517B)
Michael Silver’s laboratory in the UC Berkeley School of Optometry is recruiting healthy adults to participate in a pharmacological study of acetylcholine and spatial working memory. Participation in this study involves viewing and responding to images presented on a computer screen. The study consists of three sessions on different days, with each testing session lasting approximately 1-1.5 hours.
The first session is a screening session, and if you meet all eligibility criteria, you will be invited back for the additional sessions. Two of the subsequent sessions are pharmacology sessions. In each of these sessions, you will take a small dose of either placebo or donepezil (trade name Aricept), a commonly prescribed Alzheimer's medication. Because we must wait 3 hours after administering the medication to allow for absorption, the two pharmacology sessions last for ~4 hours each. During the 3 hours of waiting time, you would be free to do work, read, and use a computer, but you must remain in the lab. These hours will count towards your compensation.
Compensation for study participation is $12/hour for all lab sessions in addition to a $50 bonus for successfully completing all of the sessions.
To be eligible, subjects must:
1. Be at least 18 years of age
2. Have normal (20/20) or corrected to 20/20 vision. If you have corrective contact lenses or glasses, please bring them with you to all sessions.
3. Not smoke tobacco
4. Not have asthma or other lung problems or have heart arrhythmia
5. Not be on any medication that affects the central nervous system (such as medication for treatment of depression or attention deficit disorder) or take supplements that affect central nervous system function (such as St. John's Wort or Ginkgo Biloba)
6. Not be pregnant. Women of childbearing age will be provided with and asked to administer a home pregnancy test prior to each pharmacology session.
To participate or learn more, please contact Adeola Harewood at
CPHS Approval # 2010-01-567
Contact name: 
Adeola Harewood
Contact Phone: 
510 642-3134